Flow Adhesion Reverse
Blood cells are adhered to a substrate of interest (see Flow Adhesion), followed by introduction of anti-adhesive drug under flow. Remaining adherent cells are measured to generate a reverse adhesion index (rAI).
Blood samples pretreated with anti-adhesive therapies have been evaluated in in vitro flow systems to mimic prophylactic treatment. Equally important, the ability of anti-adhesive agents to reverse cell adhesion is of interest. Cells are allowed to adhere during physiologic flow. Anti-adhesive agent is flowed over adherent cells. Remaining cells are measured.